To study the state of insulin resistance which occurs in pregnancy and the possible role of cortisol in augmentation of this state.Case-control study.Khartoum teaching hospital, Khartoum north hospital, Soba hospital, Ibrahim Malek hospital, maternity hospital and Fath-Elbasheer referral centre from January to August 1996.Thirty pregnant women with gestational diabetes mellitus(GDM) and thirty pregnant women with impaired glucose tolerance(IGT) were compared with thirty control pregnant women with normal glucose tolerance.The GDM and the IGT groups were found to have significantly higher levels of serum cortisol than that of the control group [937.2 +/- 79.4 nmol/l (mean +/- S.E.) and 794.2 +/- 60.5 vs 597.3 +/- 30.9 respectively, p < 0.0006].Cortisol has a great role to play in the deterioration of glucose tolerance in pregnancy.
作者:S A, Ahmed;M H, Shalayel
来源:East African medical journal 1999 年 76卷 8期