A genetic epidemiologic investigation of breast cancer involving 389 breast cancer pedigrees including information on 14,721 individuals from the Icelandic population-based cancer registry is presented. Probands were women born in or after 1920 and reported to have breast cancer in the cancer registry. The average age of the 389 probands was 45.5 years (SD 8.92). Segregation analyses was performed evaluating residual maternal effects, a dichotomous cohort effect, and assuming the age at diagnosis followed a logistic distribution after log-transformation. Familial aggregation could be best explained by the inheritance of a high-risk allele leading to early onset breast cancer among the homozygotes, which represent approximately 2.6

作者：A B, Baffoe-Bonnie；T H, Beaty；J E, Bailey-Wilson；L A, Kiemeney；H, Sigvaldason；G, Olafsdóttir；L, Tryggvadóttir；H, Tulinius

来源：Genetic epidemiology 2000 年 18卷 1期