The molecular archaeology of the mutation spectra of tumor suppressor genes generates hypotheses concerning the etiology and molecular pathogenesis of human cancer. The spectrum of somatic mutations in the p53 gene implicates environmental carcinogens and both endogenous agents and processes in the etiology of human cancer.
作者:S P, Hussain;M H, Hollstein;C C, Harris
来源:Annals of the New York Academy of Sciences 2000 年 919卷