To evaluate the Helicobacter pylori stool antigen (HpSA) test in the assessment of H. pylori infection and the effect of omeprazole treatment on its accuracy.Study 1: 140 dyspeptic patients were enrolled in the study and defined as H. pylori positive if histology and rapid urease test, or culture alone were positive. HpSA was performed on all patients and 13C-urea breath test (UBT) on 87. Study 2: 75 patients testing positive using both UBT and HpSA, were given omeprazole 20 mg for 2 weeks (Group A) or omeprazole 40 mg for 2 weeks (Group B), or OAC for 1 week (group C). A Helicobacter pylori stool antigen test was performed on all patients on days 3, 5, 7 and 14 during treatment, and also on days 7 and 14 post-treatment in groups A and B. UBT was performed in groups A and B on days 7 and 14 during treatment, and days 7 and 14 post-treatment.80/140 patients were H. pylori positive. The sensitivity and specificity of HpSA were 93.8 and 90

作者：G, Manes；A, Balzano；G, Iaquinto；C, Ricci；M M, Piccirillo；N, Giardullo；A, Todisco；M, Lioniello；D, Vaira

来源：Alimentary pharmacology & therapeutics 2001 年 15卷 1期