A case of presumed trisomy 22 in cattle, as earlier reported, was investigated by using both chromosome banding and FISH-mapping techniques. A one year old Hereford female calf showed slow growth, brachygnathia superior, hyper-salivation. strabisbusmus convergence, macroclitoris and supernumerary nipples. At necropsy, a duplication of the uterine cervix and an extra aortic cusp were also observed. The R-banding technique revealed that BTA28 (not BTA22, as erroneously earlier reported) was involved in the trisomy. This was confirmed by FISH-mapping with chromosome-specific markers. Phenotypic characteristics achieved in cattle carrier and those earlier reported in humans carrying partial trisomy 10 were discussed.
作者:L, Iannuzzi;G P, Di Meo;P S, Leifsson;A, Eggen;K, Christensen
来源:Hereditas 2001 年 134卷 2期