It is well known that severe gingival overgrowth (GO) is induced in patients taking certain calcium channel blockers (CCB) for the treatment of hypertension, angina pectoris, and other diseases. No case has been reported to date of severe GO induced by manidipine hydrochloride (manidipine), a second generation CCB. This case report describes severe GO induced by manidipine in a female patient (43 years old) with hypertension and Sjögren syndrome (SS). The patient was administered manidipine and carteolol hydrochloride (carteolol) as antihypertensive drugs, together with bromhexine hydrochloride for the treatment of SS.At the initial periodontal examination, probing depth (PD, average 4.83 mm), plaque control record (PCR, 84.3

作者：Kyoko, Ikawa；Motohide, Ikawa；Hidetoshi, Shimauchi；Masaki, Iwakura；Seizaburo, Sakamoto

来源：Journal of periodontology 2002 年 73卷 1期