Remifentanil (Ultiva) is a recently introduced esterase-metabolized potent opioid (EMO) mu-receptor agonist with a rapid onset and offset of action for use as part of general anaesthesia in association with isoflurane or propofol or with midazolam (Dormicum) and in combination with mivacurium.A nurse from the anaesthesiology department of a hospital was found dead at home with a syringe and empty vials of Ultiva (2 mg) and of Dormicum (1 mg/mL). At autopsy several injection sites were found on her body. Usual toxicology screening operated in our laboratory revealed only the presence of benzodiazepines in blood. Regarding the case history, we decided to adapt a method specially designed for remifentanil and its inactive metabolite testing. The analytes were isolated by SPE on a Clean-Screen column. After silylation with BSTFA with 1

作者：G, Asselborn；M, Yegles；R, Wennig

来源：Acta clinica Belgica 2002 年 57 Suppl 1卷