Deficits in M1 muscarinic receptor system signaling in Alzheimer's disease (AD) prompted an analysis of components of these systems, namely, the G(q/11) protein and the regulator of G-protein signaling (RGS) 4 protein. In AD parietal cortex, total levels of G(q/11) and RGS4 proteins were significantly lower than age-matched control cases by 40
作者:Nancy A, Muma;Ramesh, Mariyappa;Kyle, Williams;John M, Lee
来源:Synapse (New York, N.Y.) 2003 年 47卷 1期