This prospective, randomized, multicentre study investigated the efficacy and safety of two tacrolimus-based regimens and their potential to withdraw steroids.In total 489 patients were randomised to receive either tacrolimus and MMF (n = 243) or tacrolimus and azathioprine (n = 246) concomitantly with steroids in both treatment groups. The initial oral dose of tacrolimus was 0.2 mg/kg/day, MMF dose was 1 g/day, azathioprine was administered at 1-2 mg/day. Steroids were tapered from 20 mg/day to 5 mg/day. From month 3 onwards, steroids were withdrawn in patients who were free from steroid-resistant rejection and who had serum creatinine concentrations < 160 mumol/L. Study duration was 6 months.Patient survival at month 6 was 98.3

作者：Z, W?odarczyk；J, Wa?aszewski；F, Perner；S, Vitko；M, Ostrowski；P, Bachleda；F, Kokot；M, Klinger；P, Szenohradsky；P, Studenik；P, Navratil；L, Asztalos；B, Rutkowski；K Kalmar, Nagy；D, Hickey

来源：Annals of transplantation 2002 年 7卷 3期