Ethics of phase 1 oncology studies: reexamining the arguments and data.-临床诊疗知识库

Ethics of phase 1 oncology studies: reexamining the arguments and data.

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作者：

Manish, Agrawal；Ezekiel J, Emanuel

来源：

JAMA 2003 年 290卷 8期

标签：

Analytical Approach Biomedical and Behavioral Research Empirical Approach

Phase 1 oncology trials are critical to improving the treatment of cancer. Critics have raised 2 fundamental ethical challenges about phase 1 cancer research: the paucity of benefits with substantial risks and poor-quality informed consent. Despite 3 decades of controversy about phase 1 oncology research, there is little critical analysis of the arguments or of the data relevant to these questions. Existing but old data reveal that about 5

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