The Vesta project aims to assess the role of traffic related air pollution in the occurrence of childhood asthma.Case-control study conducted in five French metropolitan areas between 1998 and 2000. A set of 217 pairs of matched 4 to 14 years old cases and controls were investigated. An index of lifelong exposure to traffic exhausts was constructed, using retrospective information on traffic density close to all home and school addresses since birth; this index was also calculated for the 0-3 years age period to investigate the effect of early exposures.Adjusted on environmental tobacco smoke, personal and parental allergy, and several confounders, lifelong exposure was not associated with asthma. In contrast, associations before age of 3 were significant: odds ratios for tertiles 2 and 3 of the exposure index, relative to tertile 1, exhibited a positive trend (1.48 (95

作者：D, Zmirou；S, Gauvin；I, Pin；I, Momas；F, Sahraoui；J, Just；Y, Le Moullec；F, Brémont；S, Cassadou；P, Reungoat；M, Albertini；N, Lauvergne；M, Chiron；A, Labbé

来源：Journal of epidemiology and community health 2004 年 58卷 1期