To compare the steady-state pharmacokinetics of topiramate in a large population of children and adults with epilepsy in a therapeutic drug monitoring setting.Retrospective, case-matched pharmacokinetic evaluation.Seventy children (aged 1-17 years) with epilepsy and 70 adult controls (aged 18-65 years) with epilepsy, matched for sex and comedication.Topiramate apparent oral clearance (CL/F) values were calculated from steady-state serum concentrations in children and compared with those determined in controls. Comparisons were made by means of the Mann-Whitney's U-test, or the Kruskal-Wallis test in the case of multiple comparisons. A linear regression model was used to assess potential correlation of CL/F values with age. To investigate the influence of different variables on the variability in topiramate CL/F values, a multiple regression model was developed.In the absence of enzyme-inducing comedication, mean topiramate CL/F was 42

作者：Dina, Battino；Danilo, Croci；Alessandro, Rossini；Sara, Messina；Daniela, Mamoli；Emilio, Perucca

来源：Clinical pharmacokinetics 2005 年 44卷 4期