CYP2J2 and CYP2C8 metabolize arachidonic acid (AA) to cis-epoxyeicosatrienoic acids (EETs), which play a central role in regulating renal tubular fluid-electrolyte transport and vascular tone. We hypothesized that functionally relevant polymorphisms in the CYP2J2 or CYP2C8 genes influence hypertension risk. We examined associations between CYP2J2*7 (G-50 T promoter) and CYP2C8*3 (Arg139Lys and Lys399Arg, which are in 100
作者：Lorraine M, King；James V, Gainer；Gloria L, David；Ding, Dai；Joyce A, Goldstein；Nancy J, Brown；Darryl C, Zeldin
来源：Pharmacogenetics and genomics 2005 年 15卷 1期
