To prevent pollution of the water environment by drugs, we evaluated factors affecting the elimination of drugs by inducing reactions between the pharmaceutical chemicals originating from the drugs and activated sludge (AS) in test tubes. Of 30 pharmaceutical chemicals examined, ibuprofen (IBP) as an anti-inflammatory drug most markedly inhibited the oxygen uptake rate (OUR) of AS, and its IC50 was 172 mg/l. The IBP elimination from the wastewater was due to the significant biosorption by AS and was based on the time-response and dose-response relationships. In the pharmaceutical chemical group (1) (diclofenac Na, ketoprofen, indomethacin, salicylic acid, mefenamic acid, phenylbutazone, chlorpromazine.HCl, furosemide, tolbutamide and warfarin K) showing a relatively significant OUR inhibition (IC50, 200-500 mg/l), protein binding (75-99.7
作者:Takeshi, Kumagai;Tatsuaki, Inoue;Yuichi, Mihara;Keiichi, Ebina;Katsushi, Yokota
来源:Biological & pharmaceutical bulletin 2006 年 29卷 1期