To assess the current and lifetime prevalence of psychiatric disorders among children of currently depressed mothers and to assess the association of clinical features of maternal depression (i.e., severity, chronicity, and clinical features) with child psychopathology. Mothers were participants in the STAR*D (Sequenced Treatment Alternatives to Relieve Depression) multisite trial, designed to compare effectiveness and acceptability of different treatment options for outpatients with non-psychotic major depressive disorder (MDD).Treatment-seeking mothers with a current DSM-IV diagnosis of MDD and with at least 1 child 7 to 17 years old were assessed during a major depressive episode (MDE). For each mother, 1 child was assessed (if a mother had more than 1 child, 1 was randomly selected). Maternal features assessed for this study were history of MDEs, severity of current MDE, comorbid conditions, depressive symptom features, and social functioning. Children were assessed for selected psychiatric diagnoses (Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version [K-SADS-PL]), psychopathologic symptoms and social functioning (Child Behavior Checklist), and global functioning (Children's Global Assessment Scale). Data were gathered from December 2001 to April 2004.A large proportion (72

作者：Daniel J, Pilowsky；Priya J, Wickramaratne；A John, Rush；Carroll W, Hughes；Judy, Garber；Erin, Malloy；Cheryl A, King；Gabrielle, Cerda；A Bela, Sood；Jonathan E, Alpert；Stephen R, Wisniewski；Madhukar H, Trivedi；Ardesheer, Talati；Marlene M, Carlson；Harry Hong, Liu；Maurizio, Fava；Myrna M, Weissman

来源：The Journal of clinical psychiatry 2006 年 67卷 1期