Massive lymph node metastasis of the para-aortic region and supraclavicular lymph nodes, Virchow's lymph node metastasis due to colon cancer, is extremely rare. We herein report a case of such systemic lymph node metastasis that was successfully treated with a combination of irinotecan (CPT-11) and UFT, a combination drug of tegafur and uracil. The patient was a 57-year-old woman who had a tumor in the ascending colon, and massively swollen para-aortic and supraclavicular lymph node metastasis. She was treated with combination chemotherapy of CPT-11 and UFT. The main tumor was detected as a decompressed scar, and the supraclavicular and para-aortic lymph nodes had completely disappeared after the second cycle of treatment. A histopathological examination and immunohistochemistry with cytokeratin showed complete remission of adenocarcinoma in the tumor and para-aortic lymph nodes. She remains alive without recurrence 52 months after chemotherapy. Combination chemotherapy of CPT-11 and UFT may be of potential value in the treatment of advanced colorectal carcinoma, and both histopathological and immunohistochemical confirmation of a complete remission may indicate prolonged disease-free survival.

作者：Yujiro, Fujie；Masataka, Ikeda；Iwao, Seshimo；Koji, Ezumi；Taishi, Hata；Tatsushi, Shingai；Masayoshi, Yasui；Osamu, Takayama；Hiroki, Fukunaga；Masakazu, Ikenaga；Ichiro, Takemasa；Hirofumi, Yamamoto；Masayuki, Ohue；Mitsugu, Sekimoto；Seiichi, Hirota；Morito, Monden

来源：Surgery today 2006 年 36卷 12期