Thoracic computed tomography (CT) for lung cancer screening is sensitive for the detection of early peripheral lung cancer but is not sensitive for detecting central preinvasive and microinvasive cancer. Our hypothesis is that the use of a two-step strategy, using a sputum biomarker, may increase the detection rate of lung cancer by identifying individuals at highest risk.We completed a pilot study of 561 volunteer current or former smokers 50 years of age or older, with a smoking history of more than or equal to 30 pack years. All subjects received induced sputum examination and low-dose thoracic CT scan and were offered autofluorescence bronchoscopy.CT detected 2408 pulmonary nodules, 80
作者:Annette M, McWilliams;John R, Mayo;Myeong Im, Ahn;Sharyn L S, MacDonald;Stephen C, Lam
来源:Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2006 年 1卷 1期