We evaluated the effects of the use of nonsteroidal anti-inflammatory drugs (NSAIDs) on endoscopic and histological findings in patients with rheumatoid arthritis (RA) before and after the eradication of Helicobacter pylori infection. Helicobacter pylori (H. pylori) eradication using lansoprazole 30 mg, amoxicillin 750 mg, and clarithromycin 200 mg twice daily for 1 week was conducted in 44 patients (mean age: 56.5 years) with RA. Using the updated Sydney system, endoscopic and histological findings of the greater curvature of the antrum, the greater curvature of the upper corpus, and the lesser curvature of the lower corpus were compared before and after eradication, for a mean follow-up period of 3.5 months. Overall, H. pylori eradication was successful in 32 patients (72.7

作者：Eiichi, Tanaka；Shigeo, Kamitsuji；Eisuke, Inoue；Toru, Yamada；Ayako, Nakajima；Etsuko, Takeuchi；Akiko, Yanagisawa；Ryouichi, Misaka；Mutsuo, Shigemoto；Katsuko, Yamashita；Tetsuo, Imamura；Masako, Hara；Taisuke, Tomatsu；Terunobu, Saito；Gerson, Lauren；George, Triadafilopoulos；Naoyuki, Kamatani；Gurkirpal, Singh；Hisashi, Yamanaka

来源：Modern rheumatology 2007 年 17卷 3期