To describe the incidence of hypersensitivity to abacavir and frequency of human leucocyte antigen (HLA)-B*5701 in HIV-infected Taiwanese persons.Medical records of 337 HIV-infected Taiwanese in whom abacavir-containing combination antiretroviral therapy (CART) was prescribed from 1 May 2001 to 31 December 2006 were reviewed, and HLA typing of the patients was performed in 320 patients (232 receiving abacavir and 88 not receiving abacavir) with available blood samples. HLA class I and II polymorphisms were determined by PCR with specific primers. HLA-B*5701 was further confirmed by sequence-based typing.Of the 337 patients, median CD4 count was 166.5 cells/mm3 (range, 1.0-1914.0) and 83 patients (24.6

作者：Hsin-Yun, Sun；Chien-Ching, Hung；Pi-Han, Lin；Shu-Fang, Chang；Ching-Yao, Yang；Sui-Yuan, Chang；Shan-Chwen, Chang

来源：The Journal of antimicrobial chemotherapy 2007 年 60卷 3期