The Framingham Heart Study (FHS), founded in 1948 to examine the epidemiology of cardiovascular disease, is among the most comprehensively characterized multi-generational studies in the world. Many collected phenotypes have substantial genetic contributors; yet most genetic determinants remain to be identified. Using single nucleotide polymorphisms (SNPs) from a 100K genome-wide scan, we examine the associations of common polymorphisms with phenotypic variation in this community-based cohort and provide a full-disclosure, web-based resource of results for future replication studies.Adult participants (n = 1345) of the largest 310 pedigrees in the FHS, many biologically related, were genotyped with the 100K Affymetrix GeneChip. These genotypes were used to assess their contribution to 987 phenotypes collected in FHS over 56 years of follow up, including: cardiovascular risk factors and biomarkers; subclinical and clinical cardiovascular disease; cancer and longevity traits; and traits in pulmonary, sleep, neurology, renal, and bone domains. We conducted genome-wide variance components linkage and population-based and family-based association tests.The participants were white of European descent and from the FHS Original and Offspring Cohorts (examination 1 Offspring mean age 32 +/- 9 years, 54

作者：L Adrienne, Cupples；Heather T, Arruda；Emelia J, Benjamin；Ralph B, D'Agostino；Serkalem, Demissie；Anita L, DeStefano；Josée, Dupuis；Kathleen M, Falls；Caroline S, Fox；Daniel J, Gottlieb；Diddahally R, Govindaraju；Chao-Yu, Guo；Nancy L, Heard-Costa；Shih-Jen, Hwang；Sekar, Kathiresan；Douglas P, Kiel；Jason M, Laramie；Martin G, Larson；Daniel, Levy；Chun-Yu, Liu；Kathryn L, Lunetta；Matthew D, Mailman；Alisa K, Manning；James B, Meigs；Joanne M, Murabito；Christopher, Newton-Cheh；George T, O'Connor；Christopher J, O'Donnell；Mona, Pandey；Sudha, Seshadri；Ramachandran S, Vasan；Zhen Y, Wang；Jemma B, Wilk；Philip A, Wolf；Qiong, Yang；Larry D, Atwood

来源：BMC medical genetics 2007 年 8 Suppl 1卷