We examined the risk of narcolepsy associated with active and passive smoking among genetically susceptible individuals.We conducted a population-based case-control study in King County, Wash., USA. Between 2001 and 2005, we enrolled 67 cases through physicians and public outreach, and 95 controls through random-digit dialing. Subjects were aged between 18 and 50 years and positive for HLA DQB1*0602. All subjects were administered in-person interviews about their history of active and passive smoking.We observed an increased risk of narcolepsy associated with having lived with two or more household smokers (odds ratio, OR = 5.1; 95
作者:Thanh G N, Ton;W T, Longstreth;Thomas, Koepsell
来源:Neuroepidemiology 2009 年 32卷 2期