Polymorphisms in the proinflammatory cytokine interleukin (IL)-1beta gene have been associated with systemic atherogenesis, thrombosis and rupture. The aim of this study was to investigate associations between single nucleotide polymorphisms (SNPs) in IL-1beta and intracranial hemorrhage (ICH) in the natural course of brain arteriovenous malformation (BAVM) patients.Two IL-1beta promoter SNPs (-511C-->T, -31T-->C) and 1 synonymous coding SNP in exon 5 at +3953C-->T (Phe) were genotyped in 410 BAVM patients. We performed a survival analysis of time to subsequent ICH, censoring cases at first treatment, death or last follow-up. A Cox regression analysis was performed to obtain hazard ratios (HRs) for genotypes adjusted for age, sex, Caucasian race/ethnicity and hemorrhagic presentation.Subjects with the -31 CC genotype (HR = 2.7; 95

作者：Helen, Kim；Pirro G, Hysi；Ludmila, Pawlikowska；Annie, Poon；Esteban González, Burchard；Jonathan G, Zaroff；Stephen, Sidney；Nerissa U, Ko；Achal S, Achrol；Michael T, Lawton；Charles E, McCulloch；Pui-Yan, Kwok；William L, Young

来源：Cerebrovascular diseases (Basel, Switzerland) 2009 年 27卷 2期