Recent influenza antiviral resistance studies reveal an alarming increase in both adamantanes and neuraminidase inhibitors (NAIs) resistant viral strains worldwide, particularly in Asia, Europe and the United States.In this study, we have evaluated influenza virus resistance in Central and South America.Influenza viruses, isolated from symptomatic patients throughout Central and South America in 2005-2008 were analyzed for inhibitor resistance. The M2 and NA genes of influenza viruses were sequenced and resistance was inferred by comparison with published sequences and known resistant mutations.Our results indicate that: (i) resistance to adamantanes was seen in the majority (95.5

作者：Josefina, García；Merly, Sovero；Alberto L, Torres；Jorge, Gomez；Richard, Douce；Melvin, Barrantes；Felix, Sanchez；Mirna, Jimenez；Guillermo, Comach；Ivette, de Rivera；Roberto, Agudo；Tadeusz, Kochel

来源：Influenza and other respiratory viruses 2009 年 3卷 2期