Antibody-labeled liposomes for CT imaging of atherosclerotic plaques: in vitro investigation of an anti-ICAM antibody-labeled liposome containing iohexol for molecular imaging of atherosclerotic plaques via computed tomography.-临床诊疗知识库

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We evaluated the specific binding of anti-intercellular adhesion molecule 1 (ICAM-1) conjugated liposomes (immunoliposomes, or ILs) to activated human coronary artery endothelial cells (HCAEC) with the purpose of designing a computed tomographic imaging agent for early detection of atherosclerotic plaques. Covalent attachment of anti-ICAM-1 monoclonal antibodies to pre-formed liposomes stabilized with polyethylene glycol yielded ILs, with a coupling efficiency of the ICAM-1 to the liposomes of 10

作者：Delia, Danila；Ranga, Partha；Don B, Elrod；Melinda, Lackey；S Ward, Casscells；Jodie L, Conyers

来源：Texas Heart Institute journal 2009 年 36卷 5期

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Antibody-labeled liposomes for CT imaging of atherosclerotic plaques: in vitro investigation of an anti-ICAM antibody-labeled liposome containing iohexol for molecular imaging of atherosclerotic plaques via computed tomography.

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作者：

Delia, Danila；Ranga, Partha；Don B, Elrod；Melinda, Lackey；S Ward, Casscells；Jodie L, Conyers

来源：

Texas Heart Institute journal 2009 年 36卷 5期

标签：

Atherosclerosis ICAM-1 binding sites, antibody cell adhesion molecules contrast media endothelium, vascular immunoliposome iohexol/diagnostic use tomography, X-ray computed vulnerable plaque

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