Leishmanicidal activity of saponins isolated from the leaves of Eclipta prostrata and Gymnema sylvestre.-临床诊疗知识库

Leishmanicidal activity of saponins isolated from the leaves of Eclipta prostrata and Gymnema sylvestre.

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作者：

Venkatesan Gopiesh, Khanna；Krishnan, Kannabiran；Giulia, Getti

来源：

Indian journal of pharmacology 2009 年 41卷 1期

标签：

Eclipta prostrata Gymnema sylvestre Leishmanicidal activity leishmania promastigotes saponins

To evaluate the leishmanicidal activity of saponin, dasyscyphin C of Eclipta prostrata and sapogenin, gymnemagenol from Gymnema sylvestre leaves under in vitro conditions.Dasyscyphin C/Gymnemagenol were dissolved in phosphate buffered saline (PBS) and diluted with liquid medium to obtain concentrations ranging from 1000 to 15 mug /ml. The leishmanicidal activity against leishmanial parasites, Leishmania major, Leishmania aethiopica and Leishmania tropica promastigotes was studied by the MTS assay.The Dasyscyphin C isolated from E. prostrata showed good leishmanicidal activity at 1000mug/ml concentration, with the IC(50) value of 450mug/ml against L. major promastigote and the percentage of parasitic death was 73; whereas, gymnemagenol of G. sylvestre showed only 52

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