A retrospective study based on a conventional medical practice was performed to evaluate the outcome of alendronate treatment for four years in Japanese men with osteoporosis or osteopenia and clinical risk factors for fractures.Twenty-nine Japanese men with osteoporosis or osteopenia and clinical risk factors for fractures (mean age at baseline 61.0 years) who had been treated with alendronate for over four years in our outpatient clinic were studied. Lumbar spine or total hip bone mineral density (BMD) was measured using dual energy x-ray absorptiometry, and urinary levels of cross-linked N-terminal telopeptides of type I collagen (NTX) and serum levels of bone-specific alkaline phosphatase were monitored during the four-year treatment period.Urinary NTX and serum bone-specific alkaline phosphatase levels decreased (-44.4

作者：Jun, Iwamoto；Yoshihiro, Sato；Mitsuyoshi, Uzawa；Tsuyoshi, Takeda；Hideo, Matsumoto

来源：Therapeutics and clinical risk management 2010 年 6卷