Genetic polymorphisms are important for predispositions to several human cancers. In the tumour suppressor Trp53 gene, a codon 72 polymorphism is frequent in the form of a single nucleotide polymorphism that leads to substitution of an arginine for a proline. In the present study, we analysed the association of Trp53 codon 72 polymorphs with head and neck cancer through a case-control study approach with PCR-RFLP of DNA from blood of 47 clinically confirmed patients and 52 healthy controls. The Pro (Trp5372P) and Arg (Trp5372R) allele frequencies in the healthy controls were 0.44 and 0.56, and not significantly different from those in the cancer patients at 0.56 and 0.44. The genotype distribution in the controls was 32.7

作者：K, Suresh；R, Chandirasekar；B Lakshman, Kumar；R, Venkatesan；K, Sasikala

来源：Asian Pacific journal of cancer prevention : APJCP 2010 年 11卷 6期