Quercetin and rutin are popular flavonoids in plant foods, herbs, and dietary supplements. Cyclosporine (CSP), an immunosuppressant with a narrow therapeutic window, is a substrate of P-glycoprotein (P-gp) and cytochrome P-450 3A4 (CYP3A4). This study investigated the effects of quercetin and rutin on CSP pharmacokinetics from Neoral and relevant mechanisms. Rats were orally administered Neoral with and without quercetin or rutin. The blood CSP concentration was assayed by a specific monoclonal fluorescence polarization immunoassay. The results showed that quercetin and rutin significantly decreased the C(max) of CSP by 67.8 and 63.2

作者：Chung-Ping, Yu；Ping-Ping, Wu；Yu-Chi, Hou；Shiuan-Pey, Lin；Shang-Yuan, Tsai；Chiung-Tong, Chen；Pei-Dawn Lee, Chao

来源：Journal of agricultural and food chemistry 2011 年 59卷 9期