Cardiovascular autonomic neuropathy (CAN) is a common form of autonomic dysfunction in diabetes mellitus (DM) patients, but it can be asymptomatic for years. Low baseline plasma noradrenaline levels have been found in diabetic patients, but this decrease seems to associate clinically severe autonomic neuropathy.To evaluate the impact of DM on heart rate variability (HRV) parameters and to determine the correlations with plasma adrenaline and noradrenaline, as a possible mechanism of early disruption in HRV.A group of 34 patients with type 2 diabetes mellitus, without clinical signs of CAN, was enrolled. HRV (as a measure of autonomic balance) was measured using a 24 hour ECG monitoring system in all subjects during normal daily activity. Plasma catecholamines and other laboratory markers were measured.HRV parameters are lower in DM group as compared with control group. More than half of the patients had HRV parameters below the normal range (54

作者：M, Porojan；Simona, Costin；Laura, Poant?；Anca, Cerghizan；Dana, Pop；D L, Dumitra?cu

来源：Romanian journal of internal medicine = Revue roumaine de medecine interne 2010 年 48卷 4期