The glutathione-S-transferase (GST)P1, GSTM1, and GSTT1 genotypes have been associated with an increased risk of prostate, bladder, and lung cancers. The aim of this study was to investigate the association between the GSTP1, GSTM1, and GSTT1 genotypes and the risk of prostate cancer in Korean men.The study group consisted of 166 patients with histologically confirmed prostate cancer. The control group consisted of 327 healthy, cancer-free individuals. The diagnosis of prostate cancer was made by transrectal ultrasound-guided biopsy. Patients with prostatic adenocarcinoma were divided into organ-confined (≤pT2) and non-organ-confined (≥pT3) subgroups. The histological grades were subdivided according to the Gleason score. The GSTP1, GSTM1, and GSTT1 genotypes were determined by using polymerase chain reaction-based methods. The relationship among GSTP1, GSTM1, and GSTT1 polymorphisms and prostate cancer in a case-control study was investigated.The frequency of the GSTM1 null genotype in the prostate cancer group (54.2

作者：Dong Deuk, Kwon；Jea Whan, Lee；Dong Youp, Han；Il Young, Seo；Seung Chel, Park；Hee Jong, Jeong；Yun Sik, Yang；Soo-Cheon, Chae；Kyung Sook, Na；Kum Ja, Mo；Joung Joong, Kim；Joung Sik, Rim

来源：Korean journal of urology 2011 年 52卷 4期