Metformin as an energy restriction mimetic agent for breast cancer prevention.-临床诊疗知识库

Metformin as an energy restriction mimetic agent for breast cancer prevention.

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作者：

Zongjian, Zhu；Weiqin, Jiang；Matthew D, Thompson；John N, McGinley；Henry J, Thompson

来源：

Journal of carcinogenesis 2011 年 10卷

标签：

AMP-activated protein kinase insulin mammalian target of rapamycin mammary carcinogenesis metformin

This study examined whether metformin administration inhibited chemically induced mammary carcinogenesis in rats. In cancer prevention, metformin may act (1) indirectly through reducing systemic risk factors; or (2) directly through AMPK-mediated signaling. To begin to delineate clinically relevant mechanisms for breast cancer prevention, metformin was also studied along with dietary energy restriction.Mammary cancer was induced in female Sprague--Dawley rats (50 mg/kg MNU, i.p.). Metformin was fed alone (AIN93G + 0.05 to 1.0

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