Pro-inflammatory effects and oxidative stress in lung macrophages and epithelial cells induced by ambient particulate matter.-临床诊疗知识库

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The objective of this study was to compare the toxicological effects of different source-related ambient PM10 samples in regard to their chemical composition. In this context we investigated airborne PM from different sites in Aachen, Germany. For the toxicological investigation human alveolar epithelial cells (A549) and murine macrophages (RAW264.7) were exposed from 0 to 96 h to increasing PM concentrations (0-100 μg/ml) followed by analyses of cell viability, pro-inflammatory and oxidative stress responses. The chemical analysis of these particles indicated the presence of 21 elements, water-soluble ions and PAHs. The toxicological investigations of the PM10 samples demonstrated a concentration- and time-dependent decrease in cell viability and an increase in pro-inflammatory and oxidative stress markers.

作者：S, Michael；M, Montag；W, Dott

来源：Environmental pollution (Barking, Essex : 1987) 2013 年 183卷

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Pro-inflammatory effects and oxidative stress in lung macrophages and epithelial cells induced by ambient particulate matter.

| 浏览：160

作者：

S, Michael；M, Montag；W, Dott

来源：

Environmental pollution (Barking, Essex : 1987) 2013 年 183卷

标签：

A549 Al Aluminum Arsenic As CAT COPD CYP Ca Cadmium Calcium Catalase Cd Chemical composition Chromium Chronic Obstructive Pulmonary Disease Copper Cr Cu Cytochrome Cytotoxicity ELISA Enzyme Linked Immunosorbent Assay FBS Fe Fetal Bovine Serum GPx GRc GSH GSSG Glutathione Glutathione Disulphide Glutathione Peroxidase Glutathione Reductase IL Inflammatory response Interleukin Iron K LVS Lead Low Volume Sampler Magnesium Manganese Mg Mn Murine macrophage cells NADP(+)/NADPH NF-(K)B Na Ni Nickel Nicotinamide Adenine Dinucleotide Phosphate Nuclear Factor-kappa B Oxidative stress PAH PBS PM Particulate Matter Particulate matter Pb Phosphate Buffered Saline Polycyclic Aromatic Hydrocarbons Potassium RAW264.7 RNS ROS Reactive Nitrogen Species Reactive Oxygen Species SEM SOD Scanning electron microscopy Sodium Superoxide-Dismutase TC TNF-α Total Carbon Toxicological effects Tumor Necrosis Factor-α Type II human alveolar basal epithelial cells UFP Ultrafine Particulate Matter V VOC Vanadium Volatile Organic Compounds Zinc Zn

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