Literature shows that HER2/neu positive breast cancer cells are more sensitive to radiation-induced apoptosis by targeting the epidermal growth factor receptor family tyrosine kinase. We selected 466 patients with pT1-2 HER2/neu positive tumors who received adjuvant trastuzumab for primary invasive breast cancer. Patients were divided into three groups [Quadrantectomy followed by conventional radiotherapy vs Quadrantectomy followed by Intra-operative radiotherapy with electrons vs Mastectomy without radiotherapy]. After a median follow-up of 52 months, the 5-year cumulative incidence of locoregional recurrence (LRR) was 1.9

作者：Janaina, Brollo；Maximiliano Cassilha, Kneubil；Edoardo, Botteri；Nicole, Rotmensz；Bruno Achutti, Duso；Luca, Fumagalli；Marzia Adelia, Locatelli；Carmen, Criscitiello；Visnu, Lohsiriwat；Aron, Goldhirsch；Maria Cristina, Leonardi；Roberto, Orecchia；Giuseppe, Curigliano

来源：Breast (Edinburgh, Scotland) 2013 年 22卷 5期