Higher levels of resting heart rate (HR) have been associated with sudden cardiac death (SCD) but mechanisms are poorly understood. We hypothesized that severe left ventricular systolic dysfunction (LVSD) and HR-modulating drugs explain the HR-SCD relationship.To evaluate the relationship between HR, severe LVSD, HR-modulating drugs, and SCD in the community by using a case-control approach.From the ongoing Oregon Sudden Unexpected Death Study, SCD cases (n = 378) aged ≥35 years and with electrocardiogram-documented resting HR were compared to 378 age- and gender-matched control subjects with coronary artery disease (mean age 68 ± 13 years; 69

作者：Carmen, Teodorescu；Kyndaron, Reinier；Audrey, Uy-Evanado；Karen, Gunson；Jonathan, Jui；Sumeet S, Chugh

来源：Heart rhythm : the official journal of the Heart Rhythm Society 2013 年 10卷 8期