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The optimal atrioventricular pacing delay (AVD) in cardiac resynchronization therapy (CRT) remains to be determined.To determine whether programming CRT devices to short AVD (S-AVD) will improve clinical response secondary to greater reductions in dyssynchrony.The study population comprised 1235 patients with left bundle branch block enrolled in Multicenter Automatic Defibrillator Implantation Trial in Cardiac Resynchronization Therapy (MADIT-CRT). We assessed the relationship between AVD and outcomes. Patients programmed to S-AVD (median value of <120 ms; n = 337) vs long AVD (L-AVD; ≥120 ms; n = 390) were assessed for the end points of heart failure (HF) or death, death alone, and echocardiographic response to the CRT at 1-year follow-up. Outcomes were also compared to the left bundle branch block implantable cardioverter-defibrillator-only group (n = 508).Multivariate analysis showed that patients programmed to S-AVD experienced a significant 33

作者:Andrew, Brenyo;Valentina, Kutyifa;Arthur J, Moss;Andrew, Mathias;Alon, Barsheshet;Anne-Catherine, Pouleur;Dorit, Knappe;Scott, McNitt;Bronislava, Polonsky;David T, Huang;Scott D, Solomon;Wojciech, Zareba;Ilan, Goldenberg

来源:Heart rhythm : the official journal of the Heart Rhythm Society 2013 年 10卷 8期

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作者:
Andrew, Brenyo;Valentina, Kutyifa;Arthur J, Moss;Andrew, Mathias;Alon, Barsheshet;Anne-Catherine, Pouleur;Dorit, Knappe;Scott, McNitt;Bronislava, Polonsky;David T, Huang;Scott D, Solomon;Wojciech, Zareba;Ilan, Goldenberg
来源:
Heart rhythm : the official journal of the Heart Rhythm Society 2013 年 10卷 8期
标签:
AVD Atrioventricular delay CI CRT-D Cardiac resynchronization therapy HF HR Heart failure ICD IQR L-AVD LBBB LV LVEDV LVESV MADIT-CRT Multicenter Automatic Defibrillator Implantation Trial in Cardiac Resynchronization Therapy NYHA New York Heart Association S-AVD SMART-AV Smart Delay determined AV optimization: A comparison of AV optimization methods used in cardiac resynchronization therapy atrioventricular delay cardiac resynchronization therapy-defibrillator confidence interval hazard ratio heart failure implantable cardioverter-defibrillator interquartile range left bundle branch block left ventricle/ventricular left ventricular end-diastolic volume left ventricular end-systolic volume long AVD short AVD
The optimal atrioventricular pacing delay (AVD) in cardiac resynchronization therapy (CRT) remains to be determined.To determine whether programming CRT devices to short AVD (S-AVD) will improve clinical response secondary to greater reductions in dyssynchrony.The study population comprised 1235 patients with left bundle branch block enrolled in Multicenter Automatic Defibrillator Implantation Trial in Cardiac Resynchronization Therapy (MADIT-CRT). We assessed the relationship between AVD and outcomes. Patients programmed to S-AVD (median value of <120 ms; n = 337) vs long AVD (L-AVD; ≥120 ms; n = 390) were assessed for the end points of heart failure (HF) or death, death alone, and echocardiographic response to the CRT at 1-year follow-up. Outcomes were also compared to the left bundle branch block implantable cardioverter-defibrillator-only group (n = 508).Multivariate analysis showed that patients programmed to S-AVD experienced a significant 33