Intrathecal P/Q- and R-type calcium channel blockade of spinal substance P release and c-Fos expression.-临床诊疗知识库

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Intrathecal (IT) studies have shown that several voltage sensitive calcium channels (VSCCs), such as the L-, N- and T-type may play roles in nociception and that of these only the N-type regulates primary afferent substance P (SP) release. However, the actions of other VSCCs at the spinal level are not well known. We investigated the roles of spinal P/Q- and R-type VSCCs, by IT administration of R-type (SNX-482) and P/Q-type (ω-agatoxin IVA) VSCC blockers on intraplantar formalin-evoked flinching, SP release from primary afferents and c-Fos expression in spinal dorsal horn. Intraplantar injection of formalin (2.5

作者：Tetsuji, Terashima；Qinghao, Xu；Shigeki, Yamaguchi；Tony L, Yaksh

来源：Neuropharmacology 2013 年 75卷

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Intrathecal P/Q- and R-type calcium channel blockade of spinal substance P release and c-Fos expression.

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作者：

Tetsuji, Terashima；Qinghao, Xu；Shigeki, Yamaguchi；Tony L, Yaksh

来源：

Neuropharmacology 2013 年 75卷

标签：

CGRP DRG G protein-coupled receptor GPCR IB4 IR IT N-methyl-d-aspartate NK1r NMDA Neurokinin 1 receptor SNX-482 SP Spinal cord TRPV1 VSCCs Voltage sensitive calcium channels c-Fos calcitonin gene-related peptide dorsal root ganglia immunoreactive intrathecal isolectin B4 neurokinin 1 receptor substance P transient receptor potential protein vanilloid 1 trkA tropomyosin receptor kinase A voltage-sensitive calcium channels ω-Agatoxin IVA

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