Unraveling the complexity of hepatitis B virus: from molecular understanding to therapeutic strategy in 50 years.-临床诊疗知识库

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Hepatitis B virus (HBV) is a well-known hepadnavirus with a double-stranded circular DNA genome. Although HBV was first described approximately 50 years ago, the precise mechanisms of HBV infection and effective therapeutic strategies remain unclear. Here, we focus on summarizing the complicated mechanisms of HBV replication and infection, as well as genomic factors and epigenetic regulation. Additionally, we discuss in vivo models of HBV, as well as diagnosis, prevention and therapeutic drugs for HBV. Together, the data in this 50-year review may provide new clues to elucidate molecular mechanisms of HBV pathogenesis and shed new light on the future HBV therapies.

作者：Bo, Liu；Xin, Wen；Canhua, Huang；Yuquan, Wei

来源：The international journal of biochemistry & cell biology 2013 年 45卷 9期

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Unraveling the complexity of hepatitis B virus: from molecular understanding to therapeutic strategy in 50 years.

| 浏览：91

作者：

Bo, Liu；Xin, Wen；Canhua, Huang；Yuquan, Wei

来源：

The international journal of biochemistry & cell biology 2013 年 45卷 9期

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3,5-diethoxycarbonyl-1,4-dihydrocollidine-treated 5-LOX 5-lipoxygenase AFP ALDH1 ALL ALT AR AST C/EBP-β CCAAT enhancer binding protein β CD8T lymphocytes CDH1 CHB CIITA CP CREB CRHR2 CTLs CXCR1 DDC DTP FAK FDA FXRA Food and Drug Administration HB HBIG HBV HBV therapy HBcAg HBeAg HBsAg HBx HBx protein HCC HDAC1 HO-1 Heme oxygenase-1 Hepatitis B virus Hepatocellular carcinoma IFN-α IFNAR1 IL In vivo model JAK Janus kinase MAPK MMF MTA1 NHP OPN ORFs PC PEG PH PKC PP1 PPIs RNA interference RNAi SNPs SPP1 STAT TATA binding protein TBP TGF TNF WHV alanine aminotransferase aldehyde dehydrogenase 1 androgen receptor aspartate aminotransferase cadherin-1 cccDNA chemokine (C-X-C motif) receptor 1 chronic hepatitis B class II transactivator core promoter corticotropin-releasing hormone receptor 2 covalently closed circular DNA cyclic adenosine monophosphate (cAMP) response element-binding protein diphtheria–tetanus–pertussis farnesoid X receptor alpha focal adhesion kinase hepatitis B hepatitis B X protein hepatitis B core antigen hepatitis B e antigen hepatitis B immune globulin hepatitis B surface antigen hepatitis B virus hepatocellular carcinoma heterogeneous nuclear ribonucleoproteins K histone deacetylase 1 hnRNP K interferon alpha interleukin lymphoblastic leukemia macrophagic myofasciitis metastasis-associated protein 1 miRNA microRNA mitogen-activated protein kinase non-human primates open reading frames osteopontin polyethylene glycol portal hypertension precore protein kinase C protein phosphatase 1 protein–protein interactions secreted phosphoprotein-1 signal transducer and activator of transcription single nucleotide polymorphisms transforming growth factor tumor necrosis factor type I interferon (IFN-alpha/beta) receptor 1 woodchuck hepatitis virus α-fetoprotein

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