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首页 > Advanced drug delivery reviews > Nanotechnology as a therapeutic tool to combat microbial resistance.
Nanotechnology as a therapeutic tool to combat microbial resistance.
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Use of nanoparticles is among the most promising strategies to overcome microbial drug resistance. This review article consists of three parts. The first part discusses the epidemiology of microbial drug resistance. The second part describes mechanisms of drug resistance used by microbes. The third part explains how nanoparticles can overcome this resistance, including the following: Nitric oxide-releasing nanoparticles (NO NPs), chitosan-containing nanoparticles (chitosan NPs), and metal-containing nanoparticles all use multiple mechanisms simultaneously to combat microbes, thereby making development of resistance to these nanoparticles unlikely. Packaging multiple antimicrobial agents within the same nanoparticle also makes development of resistance unlikely. Nanoparticles can overcome existing drug resistance mechanisms, including decreased uptake and increased efflux of drug from the microbial cell, biofilm formation, and intracellular bacteria. Finally, nanoparticles can target antimicrobial agents to the site of infection, so that higher doses of drug are given at the infected site, thereby overcoming resistance.

作者：Robert Y, Pelgrift；Adam J, Friedman

来源：Advanced drug delivery reviews 2013 年 65卷 13-14期

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Nanotechnology as a therapeutic tool to combat microbial resistance.
收藏
| 浏览：263
作者：
Robert Y, Pelgrift；Adam J, Friedman
来源：
Advanced drug delivery reviews 2013 年 65卷 13-14期
标签：
.OH Ag Ag NP Al(2)O(3) NP Antibacterial Antibiotic Antimicrobial Au Au NP Au NP-AMP Au@Van NP Bi NP Biofilm CFU Chitosan Cu CuO NP Drug resistant EPS Erm Fe(3)O(4) GSH GSNO H(2)O(2) HBV HIV 1 Hepatitis B virus LPS LTP NP MBC MDR MFS MIC MIC90 MPS MRAB MRSA MSSA Mg MgO NP MgX(2) NP N(2)O(3) NDM-1 NO NP NO NP/GSH NO(2) NOS NP Nanoparticle New Delhi metallo beta-lactamase 1 Nitric oxide O(2) OONO PABA PBP PPNG PVA QAC RND RNOS ROS RSNO S-nitrosoglutathione S-nitrosothiol SCC SMR SPION Silver TA genes TFC Ti TiO(2) NP TiO(2)–Ag NP VRE VRSA VatD Zn ZnO NP aluminum oxide-containing nanoparticle bismuth-containing nanoparticle chitosan NP chitosan-containing nanoparticle chitosan–Ag NP chitosan–alginate NP chitosan–alginate nanoparticle colony forming unit copper copper oxide-containing nanoparticle dinitrogen trioxide erythromycin resistance methylase extracellular polymeric substance glutathione gold gold-containing nanoparticle gold-containing nanoparticle capped with vancomycin gold-containing nanoparticle with ampicillin bound to its surface human immunodeficiency virus type 1 hydrogen peroxide hydroxyl radical l-tyrosine polyphosphate nanoparticle lipopolysaccharide magnesium magnesium halogen-containing nanoparticle magnesium oxide-containing nanoparticle magnetite major facilitator superfamily methicillin-resistant Staphylococcus aureus methicillin-sensitive Staphylococcus aureus minimum bactericidal concentration minimum inhibitory concentration mixture of hydrogel/glass composite NO NPs with glutathione (GSH) in aqueous solution mononuclear phagocyte system multidrug resistant multidrug-resistant Acinetobacter baumannii nanoparticle nanoparticle containing zero-valent Bi nanoparticles containing both TiO(2) and Ag nitric oxide synthetase nitric oxide-releasing nanoparticle nitrogen dioxide para-aminobenzoic acid penicillin binding protein penicillin-resistant Neisseria gonorrhoeae peroxynitrite polyvinyl alcohol quaternary ammonium compound reactive nitrogen oxide intermediates reactive oxygen species resistance nodulation cell division family silver silver carbene complex silver-containing nanoparticle silver-containing nanoparticle which also contains chitosan small multidrug resistance family superoxide superparamagnetic iron oxide NP thin film composite titanium titanium dioxide-containing nanoparticle toxin–antitoxin genes vancomycin-resistant Enterococcus vancomycin-resistant Staphylococcus aureus virginiamycin acetyltransferase zero-valent Bi NP zinc zinc oxide-containing nanoparticle
Use of nanoparticles is among the most promising strategies to overcome microbial drug resistance. This review article consists of three parts. The first part discusses the epidemiology of microbial drug resistance. The second part describes mechanisms of drug resistance used by microbes. The third part explains how nanoparticles can overcome this resistance, including the following: Nitric oxide-releasing nanoparticles (NO NPs), chitosan-containing nanoparticles (chitosan NPs), and metal-containing nanoparticles all use multiple mechanisms simultaneously to combat microbes, thereby making development of resistance to these nanoparticles unlikely. Packaging multiple antimicrobial agents within the same nanoparticle also makes development of resistance unlikely. Nanoparticles can overcome existing drug resistance mechanisms, including decreased uptake and increased efflux of drug from the microbial cell, biofilm formation, and intracellular bacteria. Finally, nanoparticles can target antimicrobial agents to the site of infection, so that higher doses of drug are given at the infected site, thereby overcoming resistance.

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