Multiple sclerosis (MS) occurs as a result of interaction between genetic and environmental factors. Recent data support the view that oxidative damage is one of an early event in MS tissue injury. The safe elimination of reactive oxygen species and toxins via glutathione S-transferase (GST) pathways is required in order to protect cells against reactive oxygen-induced damage. The aim of our study was to analyze the possible association of GSTM1 and GSTT1 gene polymorphisms with the susceptibility and clinical parameters of MS, in 455 consecutive patients and 366 controls.A multiplex polymerase chain reaction (PCR) was used to detect the deletions in GSTM1 and GSTT1 genes.Patients with MS had significantly higher frequency of GSTT1 null genotype compared to controls (37.36
作者:Maja, ?ivkovi?;Ivan, ?ivoti?;Evica, Din?i?;Ljiljana, Stojkovi?;Slobodan, Vojinovi?;Aleksandra, Stankovi?
来源:Journal of the neurological sciences 2013 年 334卷 1-2期