Normal tissue complication probability (NTCP) parameters for breast fibrosis: pooled results from two randomised trials.-临床诊疗知识库

Normal tissue complication probability (NTCP) parameters for breast fibrosis: pooled results from two randomised trials.

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作者：

Mukesh B, Mukesh；Emma, Harris；Sandra, Collette；Charlotte E, Coles；Harry, Bartelink；Jenny, Wilkinson；Philip M, Evans；Peter, Graham；Jo, Haviland；Philip, Poortmans；John, Yarnold；Raj, Jena

来源：

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2013 年 108卷 2期

标签：

Breast conserving treatment Breast fibrosis Breast radiotherapy Late complications NTCP

The dose-volume effect of radiation therapy on breast tissue is poorly understood. We estimate NTCP parameters for breast fibrosis after external beam radiotherapy.We pooled individual patient data of 5856 patients from 2 trials including whole breast irradiation followed with or without a boost. A two-compartment dose volume histogram model was used with boost volume as the first compartment and the remaining breast volume as second compartment. Results from START-pilot trial (n=1410) were used to test the predicted models.26.8

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