To explore the potential role of natural-resistance-associated macrophage protein 1 (NRAMP1) gene, vitamin D receptor (VDR) gene, (human leukocyte antigen, (HLA-DRB1) HLA)-DRB1 gene, and HLA-DQB1 gene polymorphisms in susceptibility to tuberculosis (TB) in the Chinese Kazakh population.A case-control study was performed on the Chinese Kazak population. Genetic polymorphisms of NRAMP1 gene (3'UTR) and VDR gene (TaqI and FokI) were analysed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and sequencing analysis in TB patients and healthy controls. Genetic polymorphisms of HLA-DRB1 gene and HLA-DQB1 gene in the two groups were detected with polymerase chain reaction-sequence-specific primers (PCR-SSPs) technique and sequencing analysis.There was statistically significant difference in the 3'UTR polymorphism between the TB patients and healthy controls in the Chinese Kazak population (P = 0.002; OR = 1.859; 95
作者:Fang, Wu;Wanjiang, Zhang;Le, Zhang;Jiangdong, Wu;Chunzhu, Li;Xianjie, Meng;Xi, Wang;Peng, He;Jie, Zhang
来源:BioMed research international 2013 年 2013卷