End-stage renal disease is associated with reduced heart rate variability (HRV), components of which generally are associated with advanced age, diabetes mellitus and left ventricular hypertrophy. We hypothesized that daily in-center hemodialysis (HD) would increase HRV.The Frequent Hemodialysis Network (FHN) Daily Trial randomized 245 patients to receive 12 months of six versus three times per week in-center HD. Two hundred and seven patients had baseline Holter recordings. HRV measures were calculated from 24-h Holter electrocardiograms at both baseline and 12 months in 131 patients and included low-frequency power (LF, a measure of sympathetic modulation), high-frequency power (HF, a measure of parasympathetic modulation) and standard deviation (SD) of the R-R interval (SDNN, a measure of beat-to-beat variation).Baseline to Month 12 change in LF was augmented by 50
作者:Christopher T, Chan;Glenn M, Chertow;John T, Daugirdas;Tom H, Greene;Peter, Kotanko;Brett, Larive;Andreas, Pierratos;John B, Stokes
来源:Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2014 年 29卷 1期