We report a multimodal optical approach using both Raman spectroscopy and optical coherence tomography (OCT) in tandem to discriminate between colonic adenocarcinoma and normal colon. Although both of these non-invasive techniques are capable of discriminating between normal and tumour tissues, they are unable individually to provide both the high specificity and high sensitivity required for disease diagnosis. We combine the chemical information derived from Raman spectroscopy with the texture parameters extracted from OCT images. The sensitivity obtained using Raman spectroscopy and OCT individually was 89

作者：Praveen C, Ashok；Bavishna B, Praveen；Nicola, Bellini；Andrew, Riches；Kishan, Dholakia；C Simon, Herrington

来源：Biomedical optics express 2013 年 4卷 10期