The aim of this study was to determine the association of n-acetyltransferase-2 polymorphisms and anti-tuberculosis drug-induced hepatotoxicity in Iranian pulmonary tuberculosis patients. Acetylating phenotypes was studied in 50 Iranian pulmonary tuberculosis patients using metabolic ratio of plasma acetyl-Isoniazid to Isoniazid. The association between hepatotoxicity and the n-acetyltransferase-2 phenotype was evaluated by using the chi-square (x(2)) test. The metabolic ratio had a bimodal distribution with an antimode value of 1.0. Based on the metabolic ratio of the mentioned patients, 20 (40

作者：Mohammad, Sistanizad；Ebrahim, Azizi；Hosein, Khalili；Mahboobeh, Hajiabdolbaghi；Kheirollah, Gholami；Reza, Mahjub

来源：Iranian journal of pharmaceutical research : IJPR 2011 年 10卷 3期