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首页 > The Journal of nutritional biochemistry > Novel insights of dietary polyphenols and obesity.
Novel insights of dietary polyphenols and obesity.
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The prevalence of obesity has steadily increased over the past three decades both in the United States and worldwide. Recent studies have shown the role of dietary polyphenols in the prevention of obesity and obesity-related chronic diseases. Here, we evaluated the impact of commonly consumed polyphenols, including green tea catechins, especially epigallocatechin gallates, resveratrol and curcumin, on obesity and obesity-related inflammation. Cellular studies demonstrated that these dietary polyphenols reduce viability of adipocytes and proliferation of preadipocytes, suppress adipocyte differentiation and triglyceride accumulation, stimulate lipolysis and fatty acid β-oxidation, and reduce inflammation. Concomitantly, the polyphenols modulate signaling pathways including the adenosine-monophosphate-activated protein kinase, peroxisome proliferator activated receptor γ, CCAAT/enhancer binding protein α, peroxisome proliferator activator receptor gamma activator 1-alpha, sirtuin 1, sterol regulatory element binding protein-1c, uncoupling proteins 1 and 2, and nuclear factor-κB that regulate adipogenesis, antioxidant and anti-inflammatory responses. Animal studies strongly suggest that commonly consumed polyphenols described in this review have a pronounced effect on obesity as shown by lower body weight, fat mass and triglycerides through enhancing energy expenditure and fat utilization, and modulating glucose hemostasis. Limited human studies have been conducted in this area and are inconsistent about the antiobesity impact of dietary polyphenols probably due to the various study designs and lengths, variation among subjects (age, gender, ethnicity), chemical forms of the dietary polyphenols used and confounding factors such as other weight-reducing agents. Future randomized controlled trials are warranted to reconcile the discrepancies between preclinical efficacies and inconclusive clinic outcomes of these polyphenols.

作者：Shu, Wang；Naima, Moustaid-Moussa；Lixia, Chen；Huanbiao, Mo；Anuradha, Shastri；Rui, Su；Priyanka, Bapat；InSook, Kwun；Chwan-Li, Shen

来源：The Journal of nutritional biochemistry 2014 年 25卷 1期

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Novel insights of dietary polyphenols and obesity.
收藏
| 浏览：241
作者：
Shu, Wang；Naima, Moustaid-Moussa；Lixia, Chen；Huanbiao, Mo；Anuradha, Shastri；Rui, Su；Priyanka, Bapat；InSook, Kwun；Chwan-Li, Shen
来源：
The Journal of nutritional biochemistry 2014 年 25卷 1期
标签：
ABCA1 ACAT ACC AGP AMPK ATGL Animal Antioxidants Apo BMI BW C/EBPα CCAAT/enhancer binding protein α CPT-1 CVD Cell DBP Dietary polyphenols EC ECG EGC EGCG FA FABP4 FAS FASN FFA FFM FM FOXO1 GPAT GPX GSSG GTC GTE GTP HDL-C HF HOMA-IR HSL Human IFN IGF-I IL LDL-C LPL LXR MAPK MCP-1 MDA MMP Molecular mechanism NF-κB Obesity PAI-1 PDEs PGC-1α PON PPARγ RCT ROS SBP SCD1 SIRT1 SOD SREBP-1c TBARS TC TG TNF-α UCP aP2 acetyl-coenzyme A carboxylase acyl-coenzyme A: cholesterol acyltransferase adenosine-monophosphate-activated protein kinase adenosine-triphosphate-binding cassette A1 adipocyte P2 protein, which is also known as aFABP, the adipocyte fatty acid binding protein or FAPB-4 adipose triglyceride lipase aminoalkyl glucosaminide 4-phosphate apolipoprotein body mass index body weight cAMP cardiovascular disease carnitine palmitoyltransferase-1 cyclic adenosine monophosphate diastolic blood pressure epicatechin epicatechin gallate epigallocatechin epigallocatechin gallate fat mass fat-free mass fatty acid fatty acid binding protein 4 fatty acid synthase forkhead box protein O1 free fatty acid glutathione disulfide glutathione peroxidase glycerol-3-phosphate acyltransferase green tea catechin green tea extracts green tea polyphenols high fat high-density lipoprotein cholesterol homeostasis model assessment of insulin resistance hormone-sensitive lipase insulin-like growth factor-I interferon interleukin lipoprotein lipase liver X receptor low-density lipoprotein cholesterol malondialdehyde matrix metalloproteinase mitogen-activated protein kinase monocyte chemoattractant protein-1 nuclear factor-κB paraoxonase peroxisome proliferator activator receptor γ peroxisome proliferator-activated receptor gamma coactivator 1-alpha phosphodiesterases plasminogen activator inhibitor type 1 randomized controlled trial reactive oxygen species sirtuin 1 stearoyl-CoA desaturase-1 sterol regulatory element-binding protein 1c superoxide dismutase systolic blood pressure thiobarbituric acid reactive substances total cholesterol triglyceride tumor necrosis factor-alpha uncoupling protein
The prevalence of obesity has steadily increased over the past three decades both in the United States and worldwide. Recent studies have shown the role of dietary polyphenols in the prevention of obesity and obesity-related chronic diseases. Here, we evaluated the impact of commonly consumed polyphenols, including green tea catechins, especially epigallocatechin gallates, resveratrol and curcumin, on obesity and obesity-related inflammation. Cellular studies demonstrated that these dietary polyphenols reduce viability of adipocytes and proliferation of preadipocytes, suppress adipocyte differentiation and triglyceride accumulation, stimulate lipolysis and fatty acid β-oxidation, and reduce inflammation. Concomitantly, the polyphenols modulate signaling pathways including the adenosine-monophosphate-activated protein kinase, peroxisome proliferator activated receptor γ, CCAAT/enhancer binding protein α, peroxisome proliferator activator receptor gamma activator 1-alpha, sirtuin 1, sterol regulatory element binding protein-1c, uncoupling proteins 1 and 2, and nuclear factor-κB that regulate adipogenesis, antioxidant and anti-inflammatory responses. Animal studies strongly suggest that commonly consumed polyphenols described in this review have a pronounced effect on obesity as shown by lower body weight, fat mass and triglycerides through enhancing energy expenditure and fat utilization, and modulating glucose hemostasis. Limited human studies have been conducted in this area and are inconsistent about the antiobesity impact of dietary polyphenols probably due to the various study designs and lengths, variation among subjects (age, gender, ethnicity), chemical forms of the dietary polyphenols used and confounding factors such as other weight-reducing agents. Future randomized controlled trials are warranted to reconcile the discrepancies between preclinical efficacies and inconclusive clinic outcomes of these polyphenols.

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