Tissue-based markers improve the accuracy of prediction models in urothelial carcinoma of the bladder (UCB). Current smoking status and cumulative exposure also affect outcomes. To evaluate whether the combination of molecular markers and smoking features further improved the prognostication of patients who underwent radical cystectomy (RC) for UCB.A total of 588 patients underwent RC and bilateral lymphadenectomy for UCB from 1995 to 2005. Immunohistochemistry for p53, p21, pRB, p27, Ki-67, and survivin was performed on tissue microarrays from the RC specimen. Smoking features were routinely assessed at diagnosis. Multivariable Cox regression models assessed time to disease recurrence and cancer-specific mortality.Of the 588 patients, 128 were never (22

作者：Lily C, Wang；Evanguelos, Xylinas；Matthew T, Kent；Luis A, Kluth；Michael, Rink；Asha, Jamzadeh；Malte, Rieken；Bashir, Al Hussein Al Awamlh；Quoc-Dien, Trinh；Maxine, Sun；Pierre I, Karakiewicz；Giacomo, Novara；James, Chrystal；Marc, Zerbib；Douglas S, Scherr；Yair, Lotan；Andrew, Vickers；Shahrokh F, Shariat

来源：Urologic oncology 2014 年 32卷 4期