A simple and sensitive HPLC-MS/MS method was developed and fully validated for the simultaneous determination of amygdalin (AD) and paeoniflorin (PF) in human plasma. For both analytes, the method exhibited high sensitivity (LLOQs of 0.6ng/mL) by selecting the ammonium adduct ions ([M+NH4](+)) as the precursor ions and good linearity over the concentration range of 0.6-2000ng/mL with the correlation coefficients>0.9972. The intra- and inter-day precision was lower than 10
作者：Xiaobing, Li；Fuguo, Shi；Pan, Gu；Lingye, Liu；Hua, He；Li, Ding
来源：Journal of pharmaceutical and biomedical analysis 2014 年 92卷
