The peribiliary glands of large bile ducts have been identified as a niche of progenitor cells that contribute to regeneration of biliary epithelium after injury. We aimed to determine whether injury to the peribiliary glands of donor livers is a risk factor for development of non-anastomotic biliary strictures (NAS) after liver transplantation.In 128 liver transplant procedures, biopsies were taken from the donor bile duct and injury was assessed using an established histological grading system. Histological severity of injury was subsequently compared in liver grafts that later developed biliary structures vs. uncomplicated liver grafts.Luminal biliary epithelial loss >50

作者：Sanna, op den Dries；Andrie C, Westerkamp；Negin, Karimian；Annette S H, Gouw；Bote G, Bruinsma；James F, Markmann；Ton, Lisman；Heidi, Yeh；Korkut, Uygun；Paulo N, Martins；Robert J, Porte

来源：Journal of hepatology 2014 年 60卷 6期