Histiocytic necrotizing lymphadenitis (HNL) is a self-limiting disease characterized by cervical lymphadenopathy and fever. Epstein-Barr virus (EBV) has been implicated as a cause of HNL in some reports but not in others. The aim of this study was to compare the clinical features and laboratory findings in children and adults with HNL and to evaluate the relationship between EBV infection and HNL.The records of patients diagnosed with biopsy-confirmed HNL at Gyeongsang National University Hospital from May 2009 to December 2012 were retrospectively reviewed. Clinical features, laboratory data (blood count, biochemistry, and serology), and computed tomography findings were collected. Immunohistochemistry for CD4, CD8, CD68, and myeloperoxidase (MPO), and in situ hybridization for EBV RNA were performed on archived lymph node biopsies from pediatric and adult patients.A total of 16 children and 31 adults were diagnosed with HNL. Fever was present in 87.5

作者：Ji-Hyun, Seo；Jong Sil, Lee；Eun-Jae, Lee；Jung-Hee, Lee；Jin Pyeong, Kim；Seung Hoon, Woo；Seong-Ki, Ahn；Oh Jin, Kwon；Jeong Seok, Hwa；Jung Je, Park

来源：International journal of pediatric otorhinolaryngology 2014 年 78卷 5期