The aim of this study was to evaluate the effects of losartan on left ventricular (LV) hypertrophy and fibrosis in patients with nonobstructive hypertrophic cardiomyopathy (HCM).Despite evidence that myocardial hypertrophy and fibrosis are mediated by angiotensin II and are important determinants of morbidity and mortality in patients with HCM, no prior studies have evaluated the effects of angiotensin receptor blockers on LV hypertrophy and fibrosis with cardiac magnetic resonance imaging.In double-blind fashion, 20 patients (3 women, 17 men; age: 51 ± 13 years) with HCM were randomly assigned to receive placebo (n = 9) or losartan 50 mg twice a day (n = 11) for 1 year. Cardiac magnetic resonance imaging was performed at baseline and 1 year to measure LV mass and extent of fibrosis as assessed by late gadolinium enhancement.There was a trend toward a significant difference in the percent change in LV mass (median [interquartile range]: +5

作者：Yuichi J, Shimada；Jonathan J, Passeri；Aaron L, Baggish；Caitlin, O'Callaghan；Patricia A, Lowry；Gia, Yannekis；Suhny, Abbara；Brian B, Ghoshhajra；Richard D, Rothman；Carolyn Y, Ho；James L, Januzzi；Christine E, Seidman；Michael A, Fifer

来源：JACC. Heart failure 2013 年 1卷 6期